MRI perfusion in determining pseudoprogression in patients with glioblastoma Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Glioblastoma
  • Magnetic Resonance Angiography
  • Neoplasm Recurrence, Local

abstract

  • We examine the role of dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion in differentiating pseudoprogression from progression in 20 consecutive patients with treated glioblastoma. MRI perfusion was performed, and relative cerebral blood volume (rCBV), relative peak height (rPH), and percent signal recovery (PSR) were measured. Pseudoprogression demonstrated lower median rCBV (P=.009) and rPH (P<.001), and higher PSR (P=.039) than progression. DSC MRI perfusion successfully identified pseudoprogression in patients who did not require a change in treatment despite radiographic worsening following chemoradiotherapy.

publication date

  • January 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4755513

Digital Object Identifier (DOI)

  • 10.1016/j.clinimag.2012.02.016

PubMed ID

  • 23151413

Additional Document Info

start page

  • 41

end page

  • 9

volume

  • 37

number

  • 1