Brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain Academic Article uri icon

Overview

MeSH Major

  • Amyloid beta-Peptides
  • Brain
  • Cerebrovascular Circulation
  • Peptide Fragments
  • Vasomotor System

abstract

  • The results provide evidence that Aβ1-40 acts on distinct luminal and abluminal vascular targets, the deleterious cerebrovascular effects of which are additive. Furthermore, the findings highlight the importance of circulating Aβ1-40 in the cerebrovascular dysfunction and may provide insight into the cerebrovascular alterations in conditions in which elevations in plasma Aβ1-40 occur.

publication date

  • January 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3530010

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.112.670976

PubMed ID

  • 23204056

Additional Document Info

start page

  • 198

end page

  • 204

volume

  • 44

number

  • 1