Frequent mutational activation of the PI3K-AKT pathway in trastuzumab-resistant breast cancer Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents, Hormonal
  • Breast Neoplasms
  • Carcinoma, Ductal, Breast
  • Neoplasm Recurrence, Local
  • Neoplasms, Hormone-Dependent
  • Phosphatidylinositol 3-Kinases

abstract

  • In this series of prospectively collected trastuzumab-refractory human breast cancers, loss of HER2 overexpression was rare, whereas activation of the PI3K-AKT pathway through loss of PTEN or PIK3CA mutation was frequently observed.

publication date

  • December 15, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3525734

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-12-1785

PubMed ID

  • 23092874

Additional Document Info

start page

  • 6784

end page

  • 91

volume

  • 18

number

  • 24