Postresection surveillance for pancreatic cancer performance status, imaging, and serum markers Review uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Pancreatic Neoplasms

abstract

  • Survivin has aroused keen interest in disparate areas of basic and translational research. This stems from the complexity of a 'survivin network', which appears to intersect multiple pathways of cell division, resistance to apoptosis, surveillance checkpoints and adaptation to unfavorable environments. Such intricacy has also engendered different models for survivin function and its implications. As antagonists of survivin are being evaluated in the clinic, a critical reassessment of the pathway, especially with respect to cell division and cell survival, is now a priority. Building a unifying model to reconcile the differing views on survivin will aid in the design and interpretation of molecularly based clinical trials targeting this network in humans.

publication date

  • November 2012

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/PPO.0b013e3182758e27

PubMed ID

  • 23187849

Additional Document Info

start page

  • 609

end page

  • 15

volume

  • 18

number

  • 6