SIRT6 puts cancer metabolism in the driver's seat Article uri icon

Overview

MeSH Major

  • Acrylamides
  • Antineoplastic Agents
  • NAD
  • Pancreatic Neoplasms
  • Piperidines

abstract

  • The rewiring of metabolism in cancer is thought to result from hyperactivation of signaling pathways that instruct cells to grow. Sebastian et al. show that loss of the tumor suppressor SIRT6 transforms cells by activating tumor metabolism. This occurs independently of mutations in canonical growth signaling pathways and reveals a tumorigenic role for cancer metabolism.

publication date

  • December 7, 2012

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2012.11.020

Additional Document Info

start page

  • 1155

end page

  • 6

volume

  • 151

number

  • 6