Ultrasound-assisted convection-enhanced delivery to the brain in vivo with a novel transducer cannula assembly: Laboratory investigation Academic Article uri icon

Overview

MeSH Major

  • Brain
  • Coloring Agents
  • Convection
  • Drug Delivery Systems
  • Evans Blue
  • Ultrasonics

abstract

  • The TCA and ultrasound device show promise to improve the distribution of infused compounds during CED. The results suggest further studies are required to optimize infusion and acoustic parameters for small compounds and for larger molecular weight compounds that are representative of promising antitumor agents. In addition, safe levels of ultrasound exposure in chronic experiments must be determined for practical clinical evaluation of UCED. Extension of these experiments to larger animal models is warranted to demonstrate efficacy of this technique.

publication date

  • December 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.3171/2012.7.JNS11144

PubMed ID

  • 22998056

Additional Document Info

start page

  • 1128

end page

  • 40

volume

  • 117

number

  • 6