MEF promotes stemness in the pathogenesis of gliomas Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • DNA-Binding Proteins
  • Glioma
  • Neoplastic Stem Cells
  • Transcription Factors

abstract

  • High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation.

publication date

  • December 7, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3812924

Digital Object Identifier (DOI)

  • 10.1016/j.stem.2012.09.012

PubMed ID

  • 23217424

Additional Document Info

start page

  • 836

end page

  • 44

volume

  • 11

number

  • 6