Mucinous carcinomas of the gallbladder clinicopathologic analysis of 15 cases identified in 606 carcinomas Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma, Mucinous
  • Gallbladder Neoplasms

abstract

  • Mucinous carcinomas constitute 2.5% of GB carcinomas. They present with an acute cholecystitis-type picture. Most MCs are a mixed-mucinous, not pure colloid, type. They are typically large and advanced tumors at the time of diagnosis and thus exhibit more-aggressive behavior than do ordinary GB carcinomas. Immunophenotypically, they differ from conventional GB adenocarcinomas by MUC2 positivity, from intestinal carcinomas by an often inverse CK7/20 profile, from pancreatic mucinous carcinomas by CDX2 negativity, and from mammary colloid carcinomas by a lack of MUC6. Unlike gastrointestinal MCs, they appear to be microsatellite stable.

publication date

  • November 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.5858/arpa.2011-0447-OA

PubMed ID

  • 23106580

Additional Document Info

start page

  • 1347

end page

  • 58

volume

  • 136

number

  • 11