PAX2 and PAX8 expression in primary and metastatic renal tumors, A comprehensive comparison Academic Article uri icon


MeSH Major

  • Biomarkers, Tumor
  • Carcinoma, Renal Cell
  • Kidney
  • Kidney Neoplasms
  • Neoplasm Proteins
  • PAX2 Transcription Factor
  • Paired Box Transcription Factors


  • Both PAX2 and PAX8 are diagnostically useful markers for both primary and metastatic renal neoplasms of a large variety of histologic types. However, PAX8 appears to be more sensitive than PAX2 in both primary and metastatic settings. PAX8 can be included in any immunohistochemical panel for the diagnosis of primary renal neoplasms. Adding PAX2 should be optional, but this would gain limited further diagnostic yield. In a metastatic setting, both PAX8 and PAX2 can be included in a panel because a small subset of metastatic RCCs are stained only with PAX2.

publication date

  • December 2012



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.5858/arpa.2012-0072-OA

PubMed ID

  • 23194047

Additional Document Info

start page

  • 1541

end page

  • 51


  • 136


  • 12