Immune tolerance and transplantation Review uri icon

Overview

MeSH Major

  • Hematopoietic Stem Cell Transplantation
  • Immune Tolerance
  • Organ Transplantation

abstract

  • Successful allogeneic hematopoietic stem cell transplantation (HSCT) and solid organ transplantation require development of a degree of immune tolerance against allogeneic antigens. T lymphocytes play a critical role in allograft rejection, graft failure, and graft-versus-host disease (GVHD). T-cell tolerance occurs by two different mechanisms: (1) depletion of self-reactive T cells during their maturation in the thymus (central tolerance), and (2) suppression/elimination of self-reactive mature T cells in the periphery (peripheral tolerance). Induction of transplant tolerance improves transplantation outcomes. Adoptive immunotherapy with immune suppressor cells including regulatory T cells, natural killer (NK)-T cells, veto cells, and facilitating cells are promising therapies for modulation of immune tolerance. Achieving mixed chimerism with the combination of thymic irradiation and T-cell-depleting antibodies, costimulatory molecule blockade with/without inhibitory signal activation, and elimination of alloreactive T cells with varying methods including pre- or post-transplant cyclophosphamide administration appear to be effective in inducing transplant tolerance.

publication date

  • December 2012

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3514882

Digital Object Identifier (DOI)

  • 10.1053/j.seminoncol.2012.10.001

PubMed ID

  • 23206840

Additional Document Info

start page

  • 629

end page

  • 42

volume

  • 39

number

  • 6