Hippo-YAP and mTOR pathways collaborate to regulate organ size
Adaptor Proteins, Signal Transducing
Hepatocyte Growth Factor
Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response to extracellular cues. A link between these pathways is revealed by the finding that YAP downregulates PTEN to promote cell growth and tissue hyperplasia.