Hippo-YAP and mTOR pathways collaborate to regulate organ size Article uri icon

Overview

MeSH Major

  • Adaptor Proteins, Signal Transducing
  • Hepatocyte Growth Factor
  • MicroRNAs
  • Phosphoproteins
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins

abstract

  • Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response to extracellular cues. A link between these pathways is revealed by the finding that YAP downregulates PTEN to promote cell growth and tissue hyperplasia.

publication date

  • December 2012

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1038/ncb2634

Additional Document Info

start page

  • 1244

end page

  • 5

volume

  • 14

number

  • 12