High-and low-dose OPG-Fc cause osteopetrosis-like changes in infant mice Academic Article uri icon

Overview

MeSH Major

  • Immunoconjugates
  • Immunoglobulin Fc Fragments
  • Osteogenesis Imperfecta
  • Osteopetrosis
  • Osteoprotegerin
  • RANK Ligand

abstract

  • Both high- and low-dose OPG-Fc treatment resulted in osteopetrotic changes in infant mice, an outcome that was not seen in studies with the RANKL inhibitor RANK-immunoglobulin Fc segment complex (RANK-Fc) or in studies with older animals. Further investigations of RANKL inhibitors are necessary before their consideration for use in children.

publication date

  • November 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3888234

Digital Object Identifier (DOI)

  • 10.1038/pr.2012.118

PubMed ID

  • 22926546

Additional Document Info

start page

  • 495

end page

  • 501

volume

  • 72

number

  • 5