Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity Review uri icon

Overview

MeSH Major

  • Genetic Loci
  • Genetic Predisposition to Disease
  • Immunity, Innate
  • Psoriasis

abstract

  • To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.

authors

publication date

  • December 2012

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3510312

Digital Object Identifier (DOI)

  • 10.1038/ng.2467

PubMed ID

  • 23143594

Additional Document Info

start page

  • 1341

end page

  • 8

volume

  • 44

number

  • 12