Targeting nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of parkinson's disease
Academic Article
Overview
MeSH Major
Disease Models, Animal
Dopamine
MPTP Poisoning
NF-E2-Related Factor 2
Parkinson Disease
Transcription, Genetic
Triterpenes
abstract
Our results indicate that activation of Nrf2/antioxidant response element (ARE) signaling by synthetic TP is directly associated with their neuroprotective effects against MPTP neurotoxicity and suggest that targeting the Nrf2/ARE pathway is a promising approach for therapeutic intervention in PD.
