Targeting nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of parkinson's disease Academic Article uri icon

Overview

MeSH Major

  • Disease Models, Animal
  • Dopamine
  • MPTP Poisoning
  • NF-E2-Related Factor 2
  • Parkinson Disease
  • Transcription, Genetic
  • Triterpenes

abstract

  • Our results indicate that activation of Nrf2/antioxidant response element (ARE) signaling by synthetic TP is directly associated with their neuroprotective effects against MPTP neurotoxicity and suggest that targeting the Nrf2/ARE pathway is a promising approach for therapeutic intervention in PD.

publication date

  • January 10, 2013

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3514006

Digital Object Identifier (DOI)

  • 10.1089/ars.2011.4491

PubMed ID

  • 22746536

Additional Document Info

start page

  • 139

end page

  • 57

volume

  • 18

number

  • 2