Association of tumor-associated trypsin inhibitor (TATI) expression with molecular markers, pathologic features and clinical outcomes of urothelial carcinoma of the urinary bladder Academic Article uri icon

Overview

MeSH Major

  • Amino Acid Transport Systems, Neutral
  • Biomarkers, Tumor
  • Carcinoma, Transitional Cell
  • Cystectomy
  • Gene Expression Regulation, Neoplastic
  • Urinary Bladder Neoplasms

abstract

  • We found that normal urothelium expresses TATI and that TATI expression decreases with advancing tumor stage. While there was no prognostic benefit to TATI when adjusted for standard clinicopathologic features, it seems to play an important biologic role in UCB pathogenesis and invasion. Its association with markers involved in the cell cycle, proliferation and inflammation serves as hypothesis for molecular interactions.

publication date

  • December 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s00345-011-0727-7

PubMed ID

  • 21739120

Additional Document Info

start page

  • 785

end page

  • 94

volume

  • 30

number

  • 6