Biogenesis of Mammalian MicroRNAs: A Global View Review uri icon

Overview

MeSH Major

  • MicroRNAs

abstract

  • MicroRNAs (miRNAs) are approximately 22-nucleotide-long non-coding RNAs that are important regulators of gene expression in eukaryotes. miRNAs are first transcribed as long primary transcripts, which then undergo a series of processing steps to produce the single-stranded mature miRNAs. This article reviews our current knowledge of the mechanism and regulation of mammalian miRNA expression and points out areas of research that may enhance our understanding of how the specificity and efficiency of miRNA production is controlled in vivo.

publication date

  • October 2012

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC5054211

Digital Object Identifier (DOI)

  • 10.1016/j.gpb.2012.06.004

PubMed ID

  • 23200133

Additional Document Info

start page

  • 239

end page

  • 45

volume

  • 10

number

  • 5