Macrophages induce differentiation of plasma cells through CXCL10/IP-10 Academic Article uri icon

Overview

MeSH Major

  • Cell Differentiation
  • Chemokine CXCL10
  • Macrophages
  • Plasma Cells

abstract

  • In tonsils, CD138(+) plasma cells (PCs) are surrounded by CD163(+) resident macrophages (Ms). We show here that human Ms (isolated from tonsils or generated from monocytes in vitro) drive activated B cells to differentiate into CD138(+)CD38(++) PCs through secreted CXCL10/IP-10 and VCAM-1 contact. IP-10 production by Ms is induced by B cell-derived IL-6 and depends on STAT3 phosphorylation. Furthermore, IP-10 amplifies the production of IL-6 by B cells, which sustains the STAT3 signals that lead to PC differentiation. IP-10-deficient mice challenged with NP-Ficoll show a decreased frequency of NP-specific PCs and lower titers of antibodies. Thus, our results reveal a novel dialog between Ms and B cells, in which IP-10 acts as a PC differentiation factor.

publication date

  • September 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3457728

Digital Object Identifier (DOI)

  • 10.1084/jem.20112142

PubMed ID

  • 22987802

Additional Document Info

start page

  • 1813

end page

  • 23, S1-2

volume

  • 209

number

  • 10