Mitochondria: Master regulators of danger signalling Review uri icon

Overview

MeSH Major

  • Apoptosis
  • Mitochondria

abstract

  • Throughout more than 1.5 billion years of obligate endosymbiotic co-evolution, mitochondria have developed not only the capacity to control distinct molecular cascades leading to cell death but also the ability to sense (and react to) multiple situations of cellular stress, including viral infection. In addition, mitochondria can emit danger signals that alert the cell or the whole organism of perturbations in homeostasis, hence promoting the induction of cell-intrinsic or systemic adaptive responses, respectively. As such, mitochondria can be considered as master regulators of danger signalling.

publication date

  • December 2012

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nrm3479

PubMed ID

  • 23175281

Additional Document Info

start page

  • 780

end page

  • 8

volume

  • 13

number

  • 12