Myeloid deletion of nuclear factor erythroid 2-related factor 2 increases atherosclerosis and liver injury Academic Article uri icon

Overview

MeSH Major

  • Atherosclerosis
  • Gene Deletion
  • Hypercholesterolemia
  • Liver Cirrhosis
  • Myeloid Cells
  • NF-E2-Related Factor 2
  • Obesity

abstract

  • Myeloid-derived Nrf2 activity attenuates atherosclerosis development and liver inflammation and fibrosis associated with obesity. Prevention of oxidative stress in macrophage and other myeloid lineage cells may be an important therapeutic target to reduce inflammation-driven complications of obesity.

publication date

  • December 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4490864

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.112.300345

PubMed ID

  • 23023374

Additional Document Info

start page

  • 2839

end page

  • 46

volume

  • 32

number

  • 12