Neutrophils come of age in chronic inflammation Review uri icon

Overview

MeSH Major

  • Autoimmune Diseases
  • Inflammation
  • Neutrophils

abstract

  • Neutrophils have long been known to participate in acute inflammation, but a role in chronic inflammatory and autoimmune diseases is now emerging. These cells are key players in the recognition and elimination of pathogens, but they also sense self components, including nucleic acids and products of sterile tissue damage. While this normally contributes to tissue repair, it can also lead to the release of highly immunogenic products that can trigger and/or amplify autoimmune pathogenic loops. Understanding the mechanisms that underlie neutrophil activation, migration, survival and their various forms of death in health and disease might provide us with new approaches to treat chronic inflammatory conditions.

publication date

  • December 2012

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3684162

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2012.09.008

PubMed ID

  • 23127555

Additional Document Info

start page

  • 671

end page

  • 7

volume

  • 24

number

  • 6