CD4+ Cells Regulate Fibrosis and Lymphangiogenesis in Response to Lymphatic Fluid Stasis Academic Article uri icon

Overview

MeSH Major

  • Adaptive Immunity
  • CD4-Positive T-Lymphocytes
  • Inflammation
  • Lymph Nodes
  • Lymphedema

abstract

  • Lymphedema and lymphatic stasis result in CD4+ cell inflammation and infiltration of mature T-helper cells. Loss of CD4+ but not CD8+ or CD25+ cell inflammation markedly decreases the pathological changes associated with lymphedema. In addition, CD4+ cells regulate lymphangiogenesis during wound repair and inflammatory lymphangiogenesis.

publication date

  • November 27, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3502174

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0049940

PubMed ID

  • 23185491

Additional Document Info

start page

  • e49940

volume

  • 7

number

  • 11