Head and Neck Sarcomas. Epidemiology, Pathology, and Management. Review uri icon

Overview

MeSH Major

  • Head and Neck Neoplasms
  • Sarcoma

abstract

  • Sarcomas of the head, neck, and skull base represent a heterogeneous group of tumors with distinct prognostic features. There have been significant improvements in characterizing these sarcomas using traditional morphologic assessments and more recent immunohistochemical analysis. Surgery is the mainstay of treatment followed by radiation therapy. Treatment modalities have changed in select pediatric sarcomas, for which new chemotherapeutic combinations have improved survival statistics. The high rate of distant failure emphasizes the need for novel systemic and directed molecular therapies. Tumor grade, size, and margin status are key factors in survival.

publication date

  • January 2013

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.nec.2012.08.010

PubMed ID

  • 23174358

Additional Document Info

start page

  • 67

end page

  • 78

volume

  • 24

number

  • 1