Driver mutations determine survival in smokers and never-smokers with stage IIIB/IV lung adenocarcinomas Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Gene Rearrangement
  • Lung Neoplasms
  • Mutation
  • Proto-Oncogene Proteins
  • Receptor Protein-Tyrosine Kinases
  • Receptor, Epidermal Growth Factor
  • Smoking
  • ras Proteins

abstract

  • Never-smokers and former/current smokers with lung adenocarcinomas were not homogeneous subgroups. Each was made up of individuals whose tumors had a unique distribution of driver mutations, which were associated with different prognoses, irrespective of smoking history.

publication date

  • December 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3424296

Digital Object Identifier (DOI)

  • 10.1002/cncr.27637

PubMed ID

  • 22605530

Additional Document Info

start page

  • 5840

end page

  • 7

volume

  • 118

number

  • 23