Complete spontaneous remission of diffuse large B-cell lymphoma of the maxillary sinus after concurrent infections
Lymphoma, Large B-Cell, Diffuse
Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of lymphoma that should be promptly treated with immunochemotherapy; rarely will patients experience spontaneous tumor regression before initiating treatment. ? We present a patient who experienced spontaneous regression of DLBCL of the maxillary sinus in the setting of concurrent pneumonia and Clostridium difficile colitis. A review, to our knowledge, of all previously reported cases of spontaneous DLBCL remission suggests that tumor location may be an important factor that affects tumor regression; almost all reported cases of spontaneous remission have occurred in patients with extranodal disease. In addition, several of the cases also occurred in the setting of concurrent infection. Although an antitumor immune response has been proposed as a likely cause of spontaneous remission, the specific mechanisms that underlie tumor regression in DLBCL are not known. Information gained through careful investigation of this phenomenon could potentially lead to a better understanding of DLBCL biology and more effective immune-mediated therapies. © 2012 Elsevier Inc.
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