Cancer- and cancer treatment-associated cognitive change: An update on the state of the science Review uri icon


MeSH Major

  • Cognition Disorders
  • Neoplasms


  • Cognitive changes associated with cancer and cancer treatments have become an increasing concern. Using breast cancer as the prototype, we reviewed the research from neuropsychological, imaging, genetic, and animal studies that have examined pre- and post-treatment cognitive change. An impressive body of research supports the contention that a subgroup of patients is vulnerable to post-treatment cognitive problems. We also propose that models of aging may be a useful conceptual framework for guiding research in this area and suggest that a useful perspective may be viewing cognitive change in patients with cancer within the context of factors that influence the trajectory of normal aging.

publication date

  • October 20, 2012



  • Review



  • eng

PubMed Central ID

  • PMC3675678

Digital Object Identifier (DOI)

  • 10.1200/JCO.2012.43.0116

PubMed ID

  • 23008308

Additional Document Info

start page

  • 3675

end page

  • 86


  • 30


  • 30