Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer Academic Article uri icon

Overview

MeSH Major

  • Colorectal Neoplasms
  • Leiomyosarcoma
  • Mediator Complex
  • Uterine Neoplasms

abstract

  • Somatic MED12 exon 2 mutations were observed in uterine leiomyosarcomas, suggesting that a subgroup of these malignant tumours may develop from a leiomyoma precursor. Mutations in CRC samples indicate that MED12 may, albeit rarely, contribute to CRC tumorigenesis.

publication date

  • November 6, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3493861

Digital Object Identifier (DOI)

  • 10.1038/bjc.2012.428

PubMed ID

  • 23132392

Additional Document Info

start page

  • 1761

end page

  • 5

volume

  • 107

number

  • 10