Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis Academic Article uri icon

Overview

MeSH Major

  • Aging
  • DNA Methylation
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins

abstract

  • Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated by X-inactivation analysis, identified somatic TET2 mutations. Recurrence testing identified TET2 mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 mutations were specific to individuals with clonal hematopoiesis without hematological malignancies and were associated with alterations in DNA methylation.

publication date

  • November 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3483435

Digital Object Identifier (DOI)

  • 10.1038/ng.2413

PubMed ID

  • 23001125

Additional Document Info

start page

  • 1179

end page

  • 81

volume

  • 44

number

  • 11