Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours Academic Article uri icon

Overview

MeSH Major

  • Gastrointestinal Neoplasms
  • Gastrointestinal Stromal Tumors
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Insulin-Like Growth Factor II
  • Receptor, IGF Type 1
  • Signal Transduction

abstract

  • The IGF pathway is deregulated in GIST with distinct patterns according to age onset and mutational status. The IGF pathway may represent a therapeutic target in patients with primary or secondary resistance to imatinib.

publication date

  • November 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3564499

Digital Object Identifier (DOI)

  • 10.1016/j.ejca.2012.05.021

PubMed ID

  • 22770876

Additional Document Info

start page

  • 3215

end page

  • 22

volume

  • 48

number

  • 17