Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours
Gastrointestinal Stromal Tumors
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Insulin-Like Growth Factor II
Receptor, IGF Type 1
The IGF pathway is deregulated in GIST with distinct patterns according to age onset and mutational status. The IGF pathway may represent a therapeutic target in patients with primary or secondary resistance to imatinib.