Phase i trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small-cell lung cancer Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Antineoplastic Combined Chemotherapy Protocols
  • Carcinoma, Large Cell
  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Squamous Cell
  • Histone Deacetylases
  • Lung Neoplasms
  • Proteasome Endopeptidase Complex

abstract

  • Induction bortezomib and vorinostat therapy followed by surgery in patients with operable NSCLC is feasible. Correlative gene-expression studies suggest new targets and cell-signaling pathways that may be important in modulating this combined therapy.

publication date

  • November 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3473142

Digital Object Identifier (DOI)

  • 10.1097/JTO.0b013e318267928d

PubMed ID

  • 23059775

Additional Document Info

start page

  • 1683

end page

  • 90

volume

  • 7

number

  • 11