Phase i trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small-cell lung cancer
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Large Cell
Carcinoma, Non-Small-Cell Lung
Carcinoma, Squamous Cell
Proteasome Endopeptidase Complex
Induction bortezomib and vorinostat therapy followed by surgery in patients with operable NSCLC is feasible. Correlative gene-expression studies suggest new targets and cell-signaling pathways that may be important in modulating this combined therapy.