Flip angle profile correction for T1 and T2 quantification with look-locker inversion recovery 2D steady-state free precession imaging Academic Article uri icon


MeSH Major

  • Algorithms
  • Image Enhancement
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging
  • Muscle, Skeletal


  • Fast methods using balanced steady-state free precession have been developed to reduce the scan time of T₁ and T₂ mapping. However, flip angle (FA) profiles created by the short radiofrequency pulses used in steady-state free precession deviate substantially from the ideal rectangular profile, causing T₁ and T₂ mapping errors. The purpose of this study was to develop a FA profile correction for T₁ and T₂ mapping with Look-Locker 2D inversion recovery steady-state free precession and to validate this method using 2D spin echo as a reference standard. Phantom studies showed consistent improvement in T₁ and T₂ accuracy using profile correction at multiple FAs. Over six human calves, profile correction provided muscle T₁ estimates with mean error ranging from excellent (-0.6%) at repetition time/FA = 18 ms/60° to acceptable (6.8%) at repetition time/FA = 4.9 ms/30°, while muscle T₂ estimates were less accurate with mean errors of 31.2% and 47.9%, respectively.

publication date

  • November 2012



  • Academic Article



  • eng

PubMed Central ID

  • PMC3342445

Digital Object Identifier (DOI)

  • 10.1002/mrm.24151

PubMed ID

  • 22294428

Additional Document Info

start page

  • 1579

end page

  • 85


  • 68


  • 5