Revisiting the old link between infection and autoimmune disease with commensals and T helper 17 cells Review uri icon

Overview

MeSH Major

  • Autoimmune Diseases
  • Intestines
  • Th17 Cells

abstract

  • Genetic composition and major histocompatibility complex polymorphisms unequivocally predispose to autoimmune disease, but environmental factors also play a critical role in precipitating disease in susceptible individuals. Notorious among these has been microbial infection. Older studies describing associations between microbial infection and autoimmune disease are now followed by new studies demonstrating correlations between susceptibility to autoimmune disease and commensal colonization of the intestinal tract. T helper 17 (T(H)17) cells have gained a prominent role in autoimmune disease, and notably, their development within the intestine has been linked to colonization with specific commensal bacteria. Here, we consider current views on how microbes, T(H)17 cells, and autoimmunity are connected. We speculate on how the intricate relationships among commensal, pathogen, and the host might ultimately determine susceptibility to autoimmune disease.

publication date

  • December 2012

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s12026-012-8311-9

PubMed ID

  • 22460741

Additional Document Info

start page

  • 50

end page

  • 68

volume

  • 54

number

  • 1-3