Altered fear learning across development in both mouse and human Academic Article uri icon

Overview

MeSH Major

  • Anxiety Disorders
  • Conditioning (Psychology)
  • Extinction, Psychological
  • Fear
  • Neuronal Plasticity

abstract

  • The only evidence-based behavioral treatment for anxiety and stress-related disorders involves desensitization techniques that rely on principles of extinction learning. However, 40% of patients do not respond to this treatment. Efforts have focused on individual differences in treatment response, but have not examined when, during development, such treatments may be most effective. We examined fear-extinction learning across development in mice and humans. Parallel behavioral studies revealed attenuated extinction learning during adolescence. Probing neural circuitry in mice revealed altered synaptic plasticity of prefrontal cortical regions implicated in suppression of fear responses across development. The results suggest a lack of synaptic plasticity in the prefrontal regions, during adolescence, is associated with blunted regulation of fear extinction. These findings provide insight into optimizing treatment outcomes for when, during development, exposure therapies may be most effective.

publication date

  • October 2, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3479553

Digital Object Identifier (DOI)

  • 10.1073/pnas.1206834109

PubMed ID

  • 22988092

Additional Document Info

start page

  • 16318

end page

  • 23

volume

  • 109

number

  • 40