Direct Immunofluorescence Testing in the Diagnosis of Immunobullous Disease, Collagen Vascular Disease, and Vascular Injury Syndromes Review uri icon

Overview

MeSH Major

  • Autoimmune Diseases
  • Connective Tissue Diseases
  • Immunoglobulin A
  • Skin Diseases, Vesiculobullous
  • Vasculitis

abstract

  • Direct and indirect immunofluorescence (IF) plays a role in the evaluation of immunobullous diseases and their mimics, and in the investigation of vascular injury syndromes and autoimmune connective tissue disease (CTD). IF mapping may be an important adjunct in the assessment of congenital epidermolysis bullosa syndromes and in Alport disease, in which antibodies are directed at certain components of the basement membrane zone to assay for their deficiency. In many cases of immunobullous and autoimmune CTDs, correlation with direct IF results is useful and often decisive in lesional evaluation and thus in patient management.

publication date

  • October 2012

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.det.2012.06.008

PubMed ID

  • 23021058

Additional Document Info

start page

  • 763

end page

  • 98, viii

volume

  • 30

number

  • 4