Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding Academic Article uri icon

Overview

MeSH Major

  • Dendrites
  • Down-Regulation
  • Ethanol
  • Extinction, Psychological
  • Prefrontal Cortex
  • Receptors, N-Methyl-D-Aspartate

abstract

  • Alcoholism is frequently co-morbid with post-traumatic stress disorder, but it is unclear how alcohol affects the neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by infralimbic mPFC neurons in vivo and functionally downregulated burst-mediating NMDA GluN1 receptors. These findings suggest that alcohol may increase risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear.

publication date

  • October 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3471649

Digital Object Identifier (DOI)

  • 10.1038/nn.3204

PubMed ID

  • 22941108

Additional Document Info

start page

  • 1359

end page

  • 61

volume

  • 15

number

  • 10