From IL-2 to IL-37: The expanding spectrum of anti-inflammatory cytokines Review uri icon


MeSH Major

  • Anti-Inflammatory Agents
  • Cytokines
  • Inflammation
  • Interleukins
  • T-Lymphocytes, Regulatory


  • Feedback regulatory circuits provided by regulatory T cells (T(reg) cells) and suppressive cytokines are an intrinsic part of the immune system, along with effector functions. Here we discuss some of the regulatory cytokines that have evolved to permit tolerance to components of self as well as the eradication of pathogens with minimal collateral damage to the host. Interleukin 2 (IL-2), IL-10 and transforming growth factor-β (TGF-β) are well characterized, whereas IL-27, IL-35 and IL-37 represent newcomers to the spectrum of anti-inflammatory cytokines. We also emphasize how information accumulated through in vitro as well as in vivo studies of genetically engineered mice can help in the understanding and treatment of human diseases.

publication date

  • October 2012



  • Review



  • eng

PubMed Central ID

  • PMC3609707

Digital Object Identifier (DOI)

  • 10.1038/ni.2406

PubMed ID

  • 22990890

Additional Document Info

start page

  • 925

end page

  • 31


  • 13


  • 10