BRAFL597 mutations in melanoma are associated with sensitivity to MEK inhibitors Academic Article uri icon

Overview

MeSH Major

  • MAP Kinase Kinase Kinases
  • Melanoma
  • Mutation
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins B-raf
  • Pyridones
  • Pyrimidinones

abstract

  • This study shows that cells harboring BRAF(L597R) mutants are sensitive to MEK inhibitor treatment, providing a rationale for routine screening and therapy of BRAF(L597R)-mutant melanoma.

publication date

  • September 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3449158

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-12-0097

PubMed ID

  • 22798288

Additional Document Info

start page

  • 791

end page

  • 7

volume

  • 2

number

  • 9