Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women Academic Article uri icon

Overview

MeSH Major

  • Aromatase
  • Cyclooxygenase 2
  • Dinoprostone
  • Inflammation
  • Mammary Glands, Human
  • Obesity

abstract

  • We show that obesity-associated inflammatory foci in the human breast are associated with elevated COX-2 levels and activation of the PGE2 → cAMP → PKA signal transduction pathway resulting in increased aromatase expression. These findings help to explain the link among obesity, low-grade chronic inflammation, and breast cancer with important clinical implications.

publication date

  • April 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3398487

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-11-0241

PubMed ID

  • 22576212

Additional Document Info

start page

  • 356

end page

  • 65

volume

  • 2

number

  • 4