Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner Academic Article uri icon

Overview

MeSH Major

  • Carotid Artery Thrombosis
  • Cyclooxygenase 2
  • Epoprostenol
  • Sirtuin 1
  • Thromboplastin

abstract

  • Modulation of SIRT1 and hence TF by prostacyclin/peroxisome proliferator-activated receptor-δ pathways not only represents a new mechanism in controlling arterial thrombus formation but also might be a useful target for therapeutic intervention in the atherothrombotic complications associated with COX-2 inhibitors.

publication date

  • September 11, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.112.097295

PubMed ID

  • 22865892

Additional Document Info

start page

  • 1373

end page

  • 84

volume

  • 126

number

  • 11