Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes Academic Article uri icon

Overview

MeSH Major

  • Activating Transcription Factor 4
  • Diabetes Mellitus, Type 1
  • Diabetic Retinopathy
  • Hyperglycemia
  • Inflammation
  • Retinal Vessels
  • STAT3 Transcription Factor

abstract

  • Taken together, our data reveal a pivotal role of ER stress and the ATF4/STAT3 pathway in retinal endothelial inflammation in diabetic retinopathy.

publication date

  • September 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3412945

Digital Object Identifier (DOI)

  • 10.1007/s00125-012-2594-1

PubMed ID

  • 22660795

Additional Document Info

start page

  • 2533

end page

  • 45

volume

  • 55

number

  • 9