High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing Academic Article uri icon

Overview

MeSH Major

  • High-Throughput Nucleotide Sequencing
  • Neoplasms

abstract

  • Despite the rapid proliferation of targeted therapeutic agents, systematic methods to profile clinically relevant tumor genomic alterations remain underdeveloped. We describe a sequencingbased approach to identifying genomic alterations in FFPE tumor samples. These studies affirm the feasibility and clinical utility of targeted sequencing in the oncology arena and provide a foundation for genomics-based stratification of cancer patients.

publication date

  • January 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3353152

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-11-0184

PubMed ID

  • 22585170

Additional Document Info

start page

  • 82

end page

  • 93

volume

  • 2

number

  • 1