Retinoic acid-related orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysema Academic Article uri icon

Overview

MeSH Major

  • DNA Damage
  • Lung
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • Pulmonary Disease, Chronic Obstructive
  • Pulmonary Emphysema

abstract

  • Taken together, these findings suggest that DNA damage may contribute to the pathogenesis of emphysema, and that Rora has a previously unrecognized role in cellular responses to genotoxicity. These findings provide a potential link between emphysema and features of premature ageing, including enhanced susceptibility to lung cancer.

publication date

  • September 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5450975

Digital Object Identifier (DOI)

  • 10.1164/rccm.201111-2023OC

PubMed ID

  • 22744720

Additional Document Info

start page

  • 412

end page

  • 9

volume

  • 186

number

  • 5