Retinoic acid-related orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysema
Nuclear Receptor Subfamily 1, Group F, Member 1
Pulmonary Disease, Chronic Obstructive
Taken together, these findings suggest that DNA damage may contribute to the pathogenesis of emphysema, and that Rora has a previously unrecognized role in cellular responses to genotoxicity. These findings provide a potential link between emphysema and features of premature ageing, including enhanced susceptibility to lung cancer.