Genomic complexity and AKT dependence in serous ovarian cancer Academic Article uri icon

Overview

MeSH Major

  • Cystadenocarcinoma, Serous
  • Ovarian Neoplasms
  • Proto-Oncogene Proteins c-akt

abstract

  • A subset of ovarian cancers exhibits AKT pathway activation and is sensitive to selective AKT inhibition. Ovarian tumors exhibit significant genetic heterogeneity and thus an individualized approach based on real-time, detailed genomic and proteomic characterization of individual tumors will be required for the successful application of PI3K/AKT pathway inhibitors in this disease.

publication date

  • January 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3274821

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-11-0170

PubMed ID

  • 22328975

Additional Document Info

start page

  • 56

end page

  • 67

volume

  • 2

number

  • 1