IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia Academic Article uri icon

Overview

MeSH Major

  • Gene Deletion
  • Immunoglobulin Heavy Chains
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Receptors, Cytokine
  • Translocation, Genetic

abstract

  • CRLF2-d and IGH@-t represent distinct subtypes of adolescent and adult ALL. Deletions of key B-cell differentiation and cell cycle control genes are highly prevalent but vary in frequency by cytogenetic subgroup. CRLF2-d, IGH@-t, and IKZF1 deletions are associated with poor outcome in adolescent and adult ALL.

publication date

  • September 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2011.40.3907

PubMed ID

  • 22851563

Additional Document Info

start page

  • 3100

end page

  • 8

volume

  • 30

number

  • 25