Association of prediabetes and diabetes with stroke symptoms: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Academic Article uri icon

Overview

MeSH

  • Aged
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged

MeSH Major

  • Diabetes Mellitus
  • Metabolic Syndrome X
  • Prediabetic State
  • Stroke

abstract

  • Stroke symptoms among individuals reporting no physician diagnosis of stroke are associated with an increased risk of future stroke. Few studies have assessed whether individuals with diabetes or prediabetes, but no physician diagnosis of stroke, have an increased prevalence of stroke symptoms. This study included 25,696 individuals aged ≥ 45 years from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study who reported no history of stroke or transient ischemic attack at baseline (2003-2007). Glucose measurements, medication use, and self-reported physician diagnosis were used to categorize participants into diabetes, prediabetes, or normal glycemia groups. The presence of six stroke symptoms was assessed using a validated questionnaire. The prevalence of any stroke symptom was higher among participants with diabetes (22.7%) compared with those with prediabetes (15.6%) or normal glycemia (14.9%). In multivariable models, diabetes was associated with any stroke symptom (prevalence odds ratio [POR] 1.28 [95% CI 1.18-1.39]) and two or more stroke symptoms (1.26 [1.12-1.43]) compared with normal glycemia. In analyses of individual stroke symptoms, diabetes was associated with numbness (1.15 [1.03-1.29]), vision loss (1.52 [1.31-1.76]), half-vision loss (1.54 [1.30-1.84]), and lost ability to understand people (1.34 [1.12-1.61]) after multivariable adjustment. No association was present between prediabetes and stroke symptoms. In this population-based study, almost one in four individuals with diabetes reported stroke symptoms, which suggests that screening for stroke symptoms in diabetes may be warranted.

publication date

  • September 2012

has subject area

  • Aged
  • Cross-Sectional Studies
  • Diabetes Mellitus
  • Female
  • Humans
  • Male
  • Metabolic Syndrome X
  • Middle Aged
  • Prediabetic State
  • Stroke

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3424995

Digital Object Identifier (DOI)

  • 10.2337/dc11-2140

PubMed ID

  • 22699292

Additional Document Info

start page

  • 1845

end page

  • 1852

volume

  • 35

number

  • 9