Efficacy of peripheral androgen blockade in prostate cancer patients with biochemical failure after definitive local therapy
5-alpha Reductase Inhibitors
Antineoplastic Combined Chemotherapy Protocols
The use of the finasteride/flutamide combination is feasible, and results in PSA declines of ≥80% in 96% of patients with serologic progression after definitive local therapy. There were no unexpected toxicities, and the change in quality of life was mild. Further evaluation of this or a similar regimen in a controlled clinical trial is warranted.