Antigenic variation and the generation of diversity in malaria parasites. Review uri icon

Overview

MeSH

  • Animals
  • Gene Expression Regulation
  • Gene Silencing
  • Genes, Protozoan
  • Genetic Variation
  • Humans
  • Immune Evasion
  • Transcriptional Activation

MeSH Major

  • Antigenic Variation
  • Antigens, Protozoan
  • Malaria, Falciparum
  • Plasmodium falciparum
  • Protozoan Proteins

abstract

  • Investigations into the genetic basis underlying antigenic variation in malaria parasites have primarily described transcriptional regulation of the large, multi-copy gene families that encode red cell surface antigens. In particular, extensive alterations to chromatin structure and subnuclear localization have been shown to play key roles in mutually exclusive expression, gene silencing and activation, and epigenetic memory. However the mechanisms responsible for the generation of sequence diversity within these gene families, a characteristic that is equally important for a parasite's ability to avoid the host's immune response, remains poorly understood in malaria. Recent work in model organisms suggests that the mechanisms controlling gene activation and silencing might also contribute to preferential recombination between antigen encoding genes, thus linking these two key processes. Copyright © 2012 Elsevier Ltd. All rights reserved.

publication date

  • August 2012

has subject area

  • Animals
  • Antigenic Variation
  • Antigens, Protozoan
  • Gene Expression Regulation
  • Gene Silencing
  • Genes, Protozoan
  • Genetic Variation
  • Humans
  • Immune Evasion
  • Malaria, Falciparum
  • Plasmodium falciparum
  • Protozoan Proteins
  • Transcriptional Activation

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3399988

Digital Object Identifier (DOI)

  • 10.1016/j.mib.2012.03.003

PubMed ID

  • 22503815

Additional Document Info

start page

  • 456

end page

  • 462

volume

  • 15

number

  • 4