Stromal cell-derived factor 1α mediates resistance to mTOR-directed therapy in pancreatic cancer Academic Article uri icon

Overview

MeSH Major

  • Chemokine CXCL12
  • Pancreatic Neoplasms
  • Receptors, CXCR4
  • Sirolimus
  • TOR Serine-Threonine Kinases

abstract

  • SDF-1α-CXCR4 signaling represents a microenvironmental factor that can maintain mTOR pathway fidelity to promote resistance to mTOR-targeted therapy in pancreatic cancer by a variety of mechanisms such as recruitment of EGFR signaling and angiogenesis.

publication date

  • January 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3432475

Digital Object Identifier (DOI)

  • 10.1593/neo.111810

PubMed ID

  • 22952422

Additional Document Info

start page

  • 690

end page

  • 701

volume

  • 14

number

  • 8