Stromal cell-derived factor 1α mediates resistance to mTOR-directed therapy in pancreatic cancer
Academic Article
Overview
MeSH Major
Chemokine CXCL12
Pancreatic Neoplasms
Receptors, CXCR4
Sirolimus
TOR Serine-Threonine Kinases
abstract
SDF-1α-CXCR4 signaling represents a microenvironmental factor that can maintain mTOR pathway fidelity to promote resistance to mTOR-targeted therapy in pancreatic cancer by a variety of mechanisms such as recruitment of EGFR signaling and angiogenesis.
