Mitochondrial dysfunction in neurodegenerative diseases Review uri icon

Overview

MeSH Major

  • Mitochondria
  • Neurodegenerative Diseases
  • Neurons

abstract

  • Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes. In most cases, there is overwhelming evidence of impaired mitochondrial function as a causative factor in these diseases. More recently, evidence has emerged for impaired mitochondrial dynamics (shape, size, fission-fusion, distribution, movement etc.) in neurodegenerative diseases such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. Here, we provide a concise overview of the major findings in recent years highlighting the importance of healthy mitochondria for a healthy neuron.

publication date

  • September 2012

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC3422529

Digital Object Identifier (DOI)

  • 10.1124/jpet.112.192138

PubMed ID

  • 22700435

Additional Document Info

start page

  • 619

end page

  • 30

volume

  • 342

number

  • 3