Comparative genomic analysis of primary versus metastatic colorectal carcinomas Academic Article uri icon

Overview

MeSH Major

  • Colorectal Neoplasms
  • DNA Copy Number Variations
  • Mutation

abstract

  • For determining RAS, BRAF, and PIK3CA mutational status, genotyping of the primary CRC is sufficient for most patients. Biopsy of a metastatic site should be considered in patients with a history of multiple primary carcinomas and in the case of TP53 for patients who have undergone interval treatment with radiation or cytotoxic chemotherapies.

publication date

  • August 20, 2012

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC3417049

Digital Object Identifier (DOI)

  • 10.1200/JCO.2011.38.2994

PubMed ID

  • 22665543

Additional Document Info

start page

  • 2956

end page

  • 62

volume

  • 30

number

  • 24