The epidemiology of depression and the evolution of treatment Review uri icon

Overview

MeSH Major

  • Antidepressive Agents
  • Depressive Disorder

abstract

  • Depression is a prevalent and pernicious disorder. About 1 in 5 US adults have at least 1 lifetime episode of major depression. Of those with depression, the majority will relapse over the long-term and many will have poor mental health outcomes and psychosocial disabilities. Over the past century, a range of treatments, including medications with varying mechanisms of action, have been developed to manage depression. Treatments from seizure therapies to an array of medications--amphetamine, tricyclic antidepressants, monoamine oxidase inhibitors, mixed-action antidepressants, selective serotonin reuptake inhibitors, and dual reuptake inhibitors--have evolved.

publication date

  • January 2012

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.4088/JCP.11096su1c.01

PubMed ID

  • 22951236

Additional Document Info

start page

  • 5

end page

  • 9

volume

  • 73

number

  • SUPPL. 1